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Richard Knox Selected Research

NRH - quinone oxidoreductase2

7/2010Quinone oxidoreductase-2-mediated prodrug cancer therapy.
3/2007NAD(P)H:quinone oxidoreductase 1 and nrh:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism.
7/2006NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs.
11/2002Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity.

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Richard Knox Research Topics

Disease

4Neoplasms (Cancer)
01/2018 - 07/2006
1Carcinoma (Carcinomatosis)
01/2014
1Diarrhea
07/2010
1Urinary Bladder Neoplasms (Bladder Cancer)
03/2007
1Neoplasm Metastasis (Metastasis)
03/2007
1Ovarian Neoplasms (Ovarian Cancer)
03/2007
1Hyperplasia
11/2002
1Carcinogenesis
11/2002
1Infections
11/2002

Drug/Important Bio-Agent (IBA)

4quinone (benzoquinone)IBA
01/2018 - 07/2006
4NRH - quinone oxidoreductase2IBA
07/2010 - 11/2002
3Oxidoreductases (Dehydrogenase)IBA
01/2018 - 07/2006
3tretazicarIBA
07/2010 - 07/2006
2NAD (NADH)IBA
01/2018 - 03/2007
2ProdrugsIBA
01/2014 - 07/2010
2EnzymesIBA
01/2014 - 11/2002
2Vitamin K 3 (Menadione)FDA Link
07/2006 - 11/2002
1Indicators and Reagents (Reagents)IBA
01/2018
1Pharmaceutical PreparationsIBA
01/2014
1DNA (Deoxyribonucleic Acid)IBA
07/2010
1Transaminases (Aminotransferases)IBA
07/2010
1Drug CombinationsIBA
07/2010
1A-factor (Streptomyces)IBA
07/2010
1Messenger RNA (mRNA)IBA
03/2007
1Complementary DNA (cDNA)IBA
07/2006
1QuinonesIBA
07/2006

Therapy/Procedure

3Therapeutics
01/2014 - 03/2007